History
The history of Cialis cannot be discussed without mentioning Pfizer's drug, Viagra (sildenafil). The FDA's approval on May 26, 1999, was a groundbreaking event for the treatment of erectile dysfunction and sales eventually reached over a billion. The FDA subsequently approved Levitra on September 19.
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In 1998, ICOS Corporation and Eli Lilly and Company formed a joint venture to further develop and commercialize the drug for erectile dysfunction, and two years later they filed a New Drug Application with the U.S. Food and Drug Administration for IC 351 (under the generic name tadalafil and the brand name Cialis). In Mart of 2002, Lilly ICOS reported to the American Urological Association that clinical trial testing in men with erectile dysfunction showed that tadalafil works for up to 38 hours, and one year later tadalafil was approved. One advantage that Cialis has over Viagra and Levitra is that tadalafil has a half-life of 17.6 hours (and thus Cialis is advertised to work for up to 38 hours, after which time there is still about one quarter of the absorbed dose in the body) as compared to 5 hours half-life for sildenafil .
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In 1994, the Botell, Washington-based biotechnology company Icos began studying IC351, which is a phosphodiesterase type 5 (PDE5) enzyme inhibitor. In 1994, Pfizer scientists discovered that sildenafil citrate, which also inhibits the PDE5 enzyme, caused patients that were participating in a clinical study of a heart medicine to have erections. Although the ICOS scientists were not testing the chemical compound IC351 for erectile dysfunction, it was recognized that the compound could have potential usefulness for the treatment of this disorder. Soon Icos received a patent in 1994 for IC351, which is structurally different from sildenafil (and vardenafil), and Phase 1 clinical trials began in 1995. In 1997, Phase 2 clinical studies were initiated in patients with erectile dysfunction and led to pivotal Phase 3 trials that supported approval.
Eli Lilly purchased ICOS Corporation for $2.2 billion dollars in 2007.
Sudden loss in hearing, sometimes with ringing in the ears , has been reported in rare instances in men taking prescription ED tablets, including CIALIS. It is not possible to determine whether these events are related directly to the PDE5 inhibitors, to other diseases or medications, to other factors. If you experience these symptoms, stop taking CIALIS and contact a doctor right away.
Important Safety Information for CIALIS� (tadalafil)
CIALIS is indicated for the treatment of erectile dysfunction.
CIALIS IS NOT FOR EVERYONE. Tell your doctor about your medical conditions and all medications, and ask if you're healthy enough for sexual activity.
Don't take CIALIS if you take nitrates, often prescribed for chest pain, as this may cause a sudden, unsafe drop in blood pressure.
Don't drink alcohol in excess (to a level of intoxication) with CIALIS, as this may increase your chances of getting dizzy or lowering your blood pressure. CIALIS does not protect against sexually transmitted diseases, including HIV. The most common side effects with CIALIS were headache and upset stomach. Backache and muscle ache were also reported, sometimes with delayed onset.
As with any ED tablet, in the rare event of priapism (an erection lasting more than 4 hours), seek immediate medical help to avoid long-term injury.
In rare instances, men taking prescription ED tablets (including CIALIS) reported a sudden decrease or loss of vision. It's not possible to determine if these events are related directly to the ED tablets or to other factors. If you have a sudden decrease or loss of vision, stop taking any ED tablet and call your doctor right away.
Sudden loss or decrease in hearing, sometimes with ringing in the ears and dizziness, has been reported in rare instances in men taking prescription ED tablets, including CIALIS. It is not possible to determine whether these events are related directly to the PDE5 inhibitors, to other diseases or medications, to other factors, or to a combination of factors. If you experience these symptoms, stop taking CIALIS and contact a doctor right away.
Cialis relaxes muscles and increases blood flow to particular areas of the body.
Cialis is used to treat erectile dysfunction (impotence).
Cialis may also be used for purposes other than those listed in this medication guide.
Individual results may vary. In clinical trials, CIALIS was shown to improve, up to 36 hours after dosing, the ability of men with ED to have a single successful intercourse attempt. CIALIS has not been studied for multiple sexual attempts per dose.
CIALIS is available by prescription only. For additional safety information, talk to your doctor about this medicine and see the full Patient Information.es with ringing in the ears and dizziness, has been reported in rare instances in men taking prescription ED tablets, including CIALIS. It is not possible to determine whether these events are related directly to the PDE5 inhibitors, to other diseases or medications, to other factors, or to a combination of factors. If you experience these symptoms, stop taking CIALIS and contact a doctor right away.
Important Safety Information for CIALIS� (tadalafil)
CIALIS is indicated for the treatment of erectile dysfunction.
CIALIS IS NOT FOR EVERYONE. Tell your doctor about your medical conditions and all medications, and ask if you're healthy enough for sexual activity.
Don't take CIALIS if you take nitrates, often prescribed for chest pain, as this may cause a sudden, unsafe drop in blood pressure.
Don't drink alcohol in excess with CIALIS, as this may increase your chances of getting dizzy or lowering your blood pressure. CIALIS does not protect against sexually transmitted diseases, including H IV. The most common side effects with CIALIS were headache and upset stomach. Backache and muscle ache were also reported, sometimes with delayed onset.
As with any ED tablet, in the rare event of priapism (an erection lasting more than 4 hours), seek immediate medical help to avoid long-term injury.
In rare instances, men taking prescription ED tablets reported a sudden decrease or loss of vision. It's not possible to determine if these events are related directly to the ED tablets or to other factors. If you have a sudden decrease or loss of vision, stop taking any ED tablet and call your doctor right away.
Sudden loss or decrease in hearing, sometimes with ringing in the ears and dizziness, has been reported in rare instances in men taking prescription ED tablets, including CIALIS. It is not possible to determine whether these events are related directly to the PD E5 inhibitors, to other diseases or medications, to other factors, or to a combination of factors. If you experience these symptoms, stop taking CIALIS.
Individual results may vary. In clinical trials, CIALIS was shown to improve, up to 36 hours after dosing, the ability of men with ED to have a single successful intercourse attempt. CIALIS has not been studied for multiple sexual attempts per dose.
November 17th, 2022 by admin
Parents of children who go to Prince George’s County (school) are to appear at a special court hearing. Their choices are stark, either have their child (children) vaccinated there and then or face imprisonment or fines. (Read content ‘Get Your Child Vaccinated Or We Will Lock You Up, Maryland, USA’…)
Posted in Medicina, Viagra, Pharma, Uncategorized | No Comments »
November 17th, 2022 by admin
Mead Johnson Nutritionals and Indiana University School of Medicine announce the development of a Center for Nutrition and Immunity that will focus on research related to infant nutrition and immune system development. (Read content ‘Mead Johnson, IU School Of Medicine Center To Focus On Infant Nutrition And Immune System Research’…)
Posted in Medicina, Viagra, Pharma, Uncategorized | No Comments »
November 17th, 2022 by admin
With the inclusion of Springer’s publications, over 7,200 titles have now been entrusted to the Portico archive. to access the complete list of titles.
Portico has been founded in response to a critical need. (Read content ‘Springer And Portico Join Forces In Electronic Archiving For Future Scholars, Researchers And Students’…)
Posted in Medicina, Viagra, Pharma, Uncategorized | No Comments »
November 17th, 2022 by Health Care
The Arizona senator, speaking to reporters about a mile from the Canadian border and just across the river from New Hampshire, said too much of health care costs are based on high drug prices.
“Drug companies and the lobbyists they pay in Washington want to keep your drug prices high.
(Read content ‘McCain calls for drug reimportation (AP)’…)
Posted in Pharmacy | No Comments »
November 17th, 2022 by admin
How does an aging driver know when it’s time to give up the keys? What can be done to maximize the safety of older drivers? (Read content ‘Senior Dilemma: Drive Safely Or Give Up The Keys?’…)
Posted in Medicina, Viagra, Pharma, Uncategorized | No Comments »
November 17th, 2022 by admin
A group of researchers of the University of Modena has investigated the role of psychological well being in premature delivery. (Read content ‘Lack Of Well Being In A Pregnant Woman May Lead To Premature Delivery’…)
Posted in Medicina, Viagra, Pharma, Uncategorized | No Comments »
November 17th, 2022 by admin
The inability to express emotions (alexithymia) is thought to be hereditary. The largest study so far has provided new data in the current issue of Psychotherapy and Psychosomatics. (Read content ‘Is The Inability To Express Emotions Hereditary?’…)
Posted in Medicina, Viagra, Pharma, Uncategorized | No Comments »
November 17th, 2022 by admin
A group of German researchers has reported on a new epidemiological study concerned with physical symptoms which are caused by psychological problems. (Read content ‘How Frequent Are Psychosomatic Symptoms In The General Population’…)
Posted in Medicina, Viagra, Pharma, Uncategorized | No Comments »
November 17th, 2022 by Health Care
Label World Named Best of the Best in Best Workplace in the Americas 2007 Competition
Label World of Rochester, NY has been awarded the Best Workplace in the Americas designation, Best of the Best 2007, for their exemplary human resources practices by the Printing Industries of America/Graphic Arts Technical Foundation.
(Read content ‘Label World Named Best of the Best in Best Workplace in the Americas 2007 Competition’…)
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November 17th, 2022 by admin
A group of Spanish researchers headed by Professor Vieta (University of Barcelona) has made a new proposal for classifying mood swings in the current issue of Psychotherapy and Psychosomatics. (Read content ‘A New Proposal For Classifying Mood Swings’…)
Posted in Medicina, Viagra, Pharma, Uncategorized | No Comments »
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